Virginia "Red" Sullivan (Felicia Day), a descendant of Little Red Riding Hood, brings her fiance home to meet her family. After she reveals that the family hunts werewolves, he is bitten by one, and she must protect her family from him.

A small town teenager in the 1960s believes her dreams of becoming a famous singer will come true when her rock star idol gets stranded in town. But a leak in a nearby chemical plant that is believed to be causing mass mutations threatens to turn her dream into a nightmare.