Five families struggle with the ups and downs of cancer treatment over the course of six years.

In post-industrial Ohio, a Chinese billionaire opens a factory in an abandoned General Motors plant, hiring two thousand Americans. Early days of hope and optimism give way to setbacks as high-tech China clashes with working-class America.

New York City playboy and professional charmer Jack Frost is rocked to discover that his one true love is engaged. As the news send him spiraling into a self-destructive cycle of reckless behavior, redemption comes from an unlikely source.