20 movies like Subject Two, ordered by similarity : The Fly(1958), Splice(2009), Alien Resurrection(1997), The Facility(2012), Big Bad Wolf(2006), Tetsuo: The Iron Man(1989), Murders in the Rue Morgue(1932), I Am Legend(2007), Possessor: Uncut(2020), The Endless(2017), The Fly(1986), Beyond Re-Animator(2003) ...
5.4/10
Sci-Fi, Horror
USA
2006
93 Minutes
Christian Oliver Dean Stapleton Courtney Mace Jurgen Jones Thomas Buesch Philip Chidel
medical student mad scientist assistant disturbing dark cabin woods experiments death suicide identity immorality metamorphosis wretched excess 2000s
A doctor invents a resurrection formula and tests it by killing his assistant over and over and over again.
7.1/10
Horror, Sci-Fi
USA
1958
94 Minutes
Al Hedison Patricia Owens Vincent Price Herbert Marshall Kathleen Freeman Betty Lou Gerson Charles Herbert Eugene Borden Torben Meyer Harry Carter Charles Tannen
scientist wife brother son mutant inspector dark shocking canada laboratory household factory teleportation experiments family death housefly quest metamorphosis sacrifice
A scientist has a horrific accident when he tries to use his newly invented teleportation device.
5.7/10
Sci-Fi, Horror
Canada|France|USA|Germany
2009
107 Minutes
Adrien Brody Sarah Polley Delphine Chaneac Simona Maicanescu David Hewlett Abigail Chu Brandon McGibbon Jonathan Payne
scientist creature husband wife brother boss thrilling offbeat melodramatic playful laboratory farm apartment woods barn science experiments unusual romance marriage evolution
Genetic engineers Clive Nicoli and Elsa Kast hope to achieve fame by successfully splicing together the DNA of different animals to create new hybrid animals for medical use.
6.2/10
Sci-Fi, Horror
USA
1997
109 Minutes
Sigourney Weaver Winona Ryder Ron Perlman Dominique Pinon Michael Wincott Dan Hedaya J.E. Freeman Brad Dourif Raymond Cruz Kim Flowers Gary Dourdan
scientist alien clone crew member astronaut dark disturbing gory thrilling space spaceship alien government ethics scientific experiments war showdown metamorphosis pursuit future
200 years after her death, Ellen Ripley is revived as a powerful human/alien hybrid clone. Along with a crew of space pirates, she must again battle the deadly aliens and stop them from reaching Earth.
4.8/10
Sci-Fi, Horror
UK
2012
82 Minutes
Aneurin Barnard Alex Reid Chris Larkin Jack Doolan Steve Evets Amit Shah Oliver Coleman Nia Roberts Skye Lourie Emily Butterfield
medical researcher participant man woman brutal creepy dark disturbing frenetic gory hospital medical building england clinic medical experiments side effects research trial drug experiment scientific experiments
Eight volunteers find themselves fighting for their lives when a drug trial goes horribly wrong.
5.3/10
Horror
USA
2006
95 Minutes
Richard Tyson Trevor Duke Kimberly J. Brown Christopher Shyer Sarah Aldrich Jason Alan Smith Adam Grimes Sarah Smith Robin Sydney Adam Hendershott
hunter survivor son beast stepfather disturbing tense dark woods cabin death werewolves party hunting chase mystery pursuit metamorphosis 2000s
After being attacked by a werewolf, a teenager believing it may have been his stepfather attempts to expose him.
7.0/10
Horror, Animation, Sci-Fi
Japan
1989
67 Minutes
pervert girlfriend businessman office worker monster ghost frightful gory disturbing wild japan apartment office street curse experiments accidental death mutation world domination fetish
A businessman accidentally kills The Metal Fetishist, who gets his revenge by slowly turning the man into a grotesque hybrid of flesh and rusty metal.
6.4/10
Horror
USA
1932
75 Minutes
Bela Lugosi Sidney Fox Leon Waycoff Bert Roach Brandon Hurst Noble Johnson D'Arcy Corrigan Arlene Francis Herman Bing
mad scientist medical student girlfriend friend mother ape dark disturbing creepy paris carnival street river laboratory medical experiments blood transfusion abduction murder science gone awry animal attack
A mad scientist seeks to mingle human blood with that of an ape, and resorts to kidnapping women for his experiments.
7.2/10
Horror, Sci-Fi, Drama
USA
2007
101 Minutes
Will Smith Alice Braga Dash Mihok Charlie Tahan Salli Richardson-Whitfield Willow Smith Darrell Foster April Grace Joanna Numata Samuel Glen James McCauley
scientist survivor dog mutant biologist dark gritty tense bleak thrilling frightening new york city apartment laboratory abandoned town street safe house death survival kidnapping
Years after a plague kills most of humanity and transforms the rest into monsters, the sole survivor in New York City struggles valiantly to find a cure.
6.5/10
Sci-Fi, Mystery & Thriller, Horror
Canada
2020
102 Minutes
Andrea Riseborough Christopher Abbott Tuppence Middleton Sean Bean Jennifer Jason Leigh Kaniehtiio Horn Rossif Sutherland Christopher Jacot
assassin executioner executive bleak creepy disturbing corporate headquarters apartment brain implants body possession assassination identity crisis metamorphosis transformation 2010s
Possessor follows an agent who works for a secretive organization that uses brain-implant technology to inhabit other people's bodies - ultimately driving them to commit assassinations for high-paying clients.
6.5/10
Horror, Mystery & Thriller, Sci-Fi
USA
2017
111 Minutes
Aaron Moorhead Aaron Moorhead Justin Benson Callie Hernandez Tate Ellington Lew Temple James Jordan Shane Brady Kira Powell Emily Montague Peter Cilella
brother cult leader cult member creature camper chilling dark thrilling intense suspenseful disturbing camp woods lake compound boat forest cult mystery mythical creatures
As kids, they escaped a UFO death cult. Now, two adult brothers seek answers after an old videotape surfaces and brings them back to where they began.
7.6/10
Horror, Sci-Fi
USA|UK|Canada
1986
95 Minutes
Jeff Goldblum Geena Davis John Getz Joy Boushel Leslie Carlson George Chuvalo Michael Copeman David Cronenberg Carol Lazare Shawn Hewitt
scientist girlfriend reporter editor mutant creepy tense thrilling laboratory apartment clinic teleportation experiments mutation abortion relationships failure quest love fall
A brilliant but eccentric scientist begins to transform into a giant man/fly hybrid after one of his experiments goes horribly wrong.
5.8/10
Horror, Comedy
Spain|USA
2003
93 Minutes
Jeffrey Combs Jason Barry Elsa Pataky Enrique Arce Simón Andreu Santiago Segura Tommy Dean Musset Bárbara Elorrieta Ángel Plana Javier Sandoval Lolo Herrero
mad scientist prison official reporter doctor cellmate warden offbeat dark thrilling amusing prison cell laboratory death reanimating the dead experiments survival science gone awry obsession discovery
After 13 years in prison, the mad scientist from Re-Animator (1985) gets a new chance to experiment with the arrival of a young prison doctor, who secretly hopes to learn to reanimate dead people. Good intentions turn to horror.
4.5/10
Mystery & Thriller, Sci-Fi, Horror
Canada
2016
89 Minutes
Alanna LeVierge Nina Kiri Adam Christie Kate Fenton Michael Lipka Brooke Henderson Glen Reid Deborah Jayne Reilly Smith
bike messenger courier evil twin thrilling tense intense frightening disturbing dark hospital house accident recovery hallucinations science fiction horror metamorphosis escape 2010s
After a traumatic accident, a bike courier begins to experience blackouts and hallucinations. She soon discovers that she's being dangerously influenced and even controlled by her unborn twin.
7.0/10
Horror, Comedy
USA
2011
95 Minutes
Kristen Connolly Chris Hemsworth Anna Hutchison Fran Kranz Jesse Williams Richard Jenkins Bradley Whitford Brian J. White Amy Acker Tom Lenk Sigourney Weaver
college student friend girlfriend love interest zombie scientist frightening cheeky shocking tense amusing hilarious cabin forest outdoors cellar woods laboratory vacation isolation
Five friends go for a break at a remote cabin, where they get more than they bargained for, discovering the truth behind the cabin in the woods.
4.5/10
Mystery & Thriller, Sci-Fi, Horror
USA
2015
82 Minutes
Lance Henriksen Camille Balsamo Matt Winston Reid Collums Milla Bjorn Winston James Francis Mike Estime Edwin H. Bravo Giovonnie Samuels
student crew member monster mutant agent inuit chilling creepy dark frightening gripping intense bering sea boat alaska glacier mutilation experiments fear feud
While studying the effects of global warming on a pod of whales, grad students on a crabbing vessel and its crew uncover frozen Soviet space shuttle and unintentionally release a monstrous organism from it.
7.6/10
Horror
USA
1931
97 Minutes
Fredric March Miriam Hopkins Rose Hobart Holmes Herbert Halliwell Hobbes Edgar Norton Arnold Lucy Tempe Pigott Eric Wilton Douglas Walton John Rogers
scientist murderer lunatic sexy woman fiancée dark creepy gritty london england laboratory scientific experiments madness violence addiction discovery wretched excess metamorphosis 1880s
Dr. Jekyll faces horrible consequences when he lets his dark side run wild with a potion that transforms him into the animalistic Mr. Hyde.
3.5/10
Sci-Fi, Horror
USA
2016
87 Minutes
Jessica Lee Keller Lindsey Sporrer Greg Evigan Leslie Easterbrook Dillon Cavitt Evan Miller Sarah Joy Byington Heath Allyn
scientist daughter father bird friend millionaire brutal suspenseful thrilling shocking spectacular intense laboratory woods ranch wilderness home aviary horror killer animals
When Maddy Stern discovers her father has gone missing during a routine birdwatching excursion, she and her college pals trek out into the wilderness to find him, only to end up in a ... See full summary »
6.8/10
Sci-Fi, Mystery & Thriller, Adventure
UK
2018
115 Minutes
Natalie Portman Jennifer Jason Leigh Gina Rodriguez Tessa Thompson Tuva Novotny Oscar Isaac Benedict Wong David Gyasi Sonoya Mizuno John Schwab
biologist soldier husband monster creature scientist creepy dark uneasy frightening thrilling base camp house woods forest secret location cabin creatures mutation saving the planet
A biologist signs up for a dangerous, secret expedition into a mysterious zone where the laws of nature don't apply.
5.1/10
Horror
USA
2006
94 Minutes
Lori Heuring Scout Taylor-Compton Chloë Grace Moretz Geoffrey Lewis Velizar Binev Ben Cross Chris Jamba Michael McCoy Martin McDougall Julie Rogers Craig Vye
widow daughter teen girl young girl zombie millionaire gory disturbing dark pennsylvania small town woods cabin zombies vengeance death mining revenge escape 2000s
Karen, Sarah, and Emma Tunney are all moving to a small town in Pennsylvania where, unknown to them, in 1913, a horrid mine accident trapped dozens of children alive, underground. But there's a problem. They're still alive.
7.7/10
Sci-Fi, Anime, Action, Adventure
Japan
2006
90 Minutes
scientist psychiatrist police officer patient villain creative crafty dreamy disturbing tokyo apartment hospital car suicide weapons mistaken identity dreams investigation deception discovery
When a machine that allows therapists to enter their patients' dreams is stolen, all Hell breaks loose. Only a young female therapist, Paprika, can stop it.
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